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Congenital malformations in diabetic offspring.

P Temesio, R Belitzky, L Gallego

Acta Diabetologica Latina

|September 1, 1977

Summary

Congenital malformations (CM) occurred in 9.8% of deliveries to diabetic mothers. This retrospective study found no statistically significant link between CM prevalence and maternal age, diabetes class, angiopathy, treatment, or metabolic control.

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Area of Science:

Obstetrics and Gynecology
Neonatology
Endocrinology

Background:

Maternal diabetes is a known risk factor for congenital malformations (CM).
Understanding the specific risk factors in diabetic pregnancies is crucial for improving outcomes.
Previous research suggests various maternal and disease-related factors may influence CM development.

Purpose of the Study:

To investigate the prevalence of congenital malformations (CM) in deliveries to diabetic mothers.
To analyze the association between CM and maternal age, diabetes class, angiopathy, treatment, and metabolic control in diabetic pregnancies.

Main Methods:

Retrospective study design.
Analysis of 215 deliveries from diabetic mothers at Hospital de Clínicas, Montevideo, Uruguay.
Statistical evaluation of potential risk factors including maternal age, diabetes classification, angiopathy, treatment, and metabolic control.

Main Results:

The overall prevalence of congenital malformations (CM) in the study cohort was 9.8%.
No statistically significant associations were found between the prevalence of CM and maternal age.
No statistically significant associations were found between the prevalence of CM and maternal diabetes class, angiopathy, treatment, or metabolic control.

Conclusions:

The study identified a 9.8% prevalence of congenital malformations in deliveries to diabetic mothers.
Key maternal and diabetes-related factors analyzed did not show a statistically significant link to CM prevalence in this cohort.
Further research may be needed to elucidate potential contributing factors to congenital malformations in diabetic pregnancies.

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