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Related Experiment Videos

[Ranitidine (Zantic) for aspiration prevention].

H Schaer

    Der Anaesthesist
    |July 1, 1983
    PubMed
    Summary

    A single 300 mg dose of ranitidine effectively prevents gastric acid aspiration by increasing stomach pH. This dosage provides adequate protection for procedures scheduled the following morning, offering a convenient prophylactic option.

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    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Gastroenterology

    Background:

    • H2-receptor antagonists are used to prevent gastric acid aspiration.
    • Current dosage schedules for H2-receptor antagonists are often impractical for clinical use.
    • Gastric acid aspiration poses a significant risk during anesthesia.

    Purpose of the Study:

    • To evaluate the efficacy of a single, evening dose of ranitidine on gastric pH and volume.
    • To determine an optimal dosage regimen for ranitidine in preventing gastric acid aspiration.
    • To compare the effectiveness of ranitidine with cimetidine.

    Main Methods:

    • Investigated the effect of ranitidine 300 mg and 150 mg, and cimetidine 400 mg on gastric secretion.
    • Administered a single dose at 22:00 the previous evening.
    • Measured gastric pH and volume at 08:00 the following morning.

    Main Results:

    • Ranitidine 300 mg consistently increased gastric pH to above 3.5 by 08:00.
    • Ranitidine 150 mg and cimetidine 400 mg did not achieve satisfactory pH levels.
    • An additional dose of ranitidine at 07:00 may be necessary for procedures starting after 09:00.

    Conclusions:

    • A single 300 mg dose of ranitidine is an effective prophylactic measure against gastric acid aspiration.
    • This regimen simplifies patient care and reduces inconvenience for staff.
    • Ranitidine 300 mg offers a practical and efficient solution for pre-anesthetic gastric acid control.

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