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[Comparative study of ORG NC 45 and pancuronium during anesthesia]
Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1983
Summary
ORG NC 45 offers a shorter duration of muscle relaxation compared to pancuronium, with faster recovery and less accumulation. This makes it suitable for tracheal intubation and procedures requiring brief muscle paralysis.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Muscle relaxants are crucial in anesthesia for facilitating tracheal intubation and surgical procedures.
- Pancuronium has been a standard neuromuscular blocking agent, but shorter-acting alternatives are sought.
Purpose of the Study:
- To compare the muscle relaxant effects of ORG NC 45 and pancuronium in anesthetized patients.
- To evaluate the onset, duration, and recovery characteristics of both agents for tracheal intubation and surgical relaxation.
Main Methods:
- A comparative study involving anesthetized patients with normal liver and renal functions.
- Neuromuscular blockade was monitored via adductor pollicis muscle strength elicited by ulnar nerve stimulation.
- Doses of 100 mcg/kg for intubation followed by 25 mcg/kg repeat doses as needed were administered.
Main Results:
- ORG NC 45 demonstrated a significantly shorter duration of action and was non-cumulative compared to pancuronium.
- Adequate conditions for tracheal intubation were achieved 3-4 minutes post-administration of 100 mcg/kg ORG NC 45.
- Recovery to 75% muscle strength occurred at 46 minutes for ORG NC 45 versus 100 minutes for pancuronium.
- Repeat injection intervals averaged 20 minutes for ORG NC 45 and 40 minutes for pancuronium.
Conclusions:
- ORG NC 45 is a superior muscle relaxant to pancuronium due to its shorter duration and non-cumulative properties.
- Its rapid onset and recovery profile make it advantageous for procedures requiring precise control over neuromuscular blockade, like tracheal intubation.