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Midazolam and anaesthesia.
British Journal of Clinical Pharmacology
|January 1, 1983
Summary
Midazolam offers advantages in anesthesia due to its rapid metabolism and good tissue tolerance. It is effective for oral or intramuscular premedication and anesthesia induction when combined with analgesics.
Area of Science:
- Anesthesiology and Pharmacology
Background:
- Midazolam exhibits unique physico-chemical properties facilitating rapid biotransformation.
- Its favorable characteristics make it a valuable agent in specific anesthetic applications.
Purpose of the Study:
- To highlight the benefits of midazolam in anesthesia.
- To detail its suitability for various administration routes and anesthetic stages.
Main Methods:
- Physico-chemical property analysis.
- Pharmacokinetic and pharmacodynamic evaluation (implied).
- Clinical application review (implied).
Main Results:
- Excellent local tissue tolerance following intramuscular injection.
- Absence of venous irritation.
- Rapid onset of metabolism enabling precise control over anesthetic action.
Conclusions:
- Midazolam is well-suited for oral and intramuscular premedication.
- It serves as an effective agent for anesthesia induction, particularly with analgesics.