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[Human plasma lactic dehydrogenase activity: individual variations and reference intervals].

F Schiele, M M Galteau, G Siest

    Annales De Biologie Clinique
    |January 1, 1977
    PubMed
    Summary
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    Total lactate dehydrogenase (LDH) activity varies significantly with age, particularly in children. Socio-professional status also influences LDH levels, while adult morphology shows minimal impact on this enzyme

    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Human Physiology

    Context:

    • Establishing reference intervals for enzymes is crucial for accurate clinical diagnosis.
    • Lactate dehydrogenase (LDH) is a key enzyme in cellular metabolism with diagnostic relevance.
    • Understanding factors influencing enzyme activity is essential for interpreting laboratory results.

    Purpose:

    • To determine reference intervals for total lactate dehydrogenase (LDH) activity in a large population.
    • To investigate variations in LDH activity based on demographic and lifestyle factors.
    • To identify key determinants of LDH levels in diverse individuals.

    Summary:

    • Frequent values for total lactate dehydrogenase (LDH) activity were established from a population of 87,600 individuals.

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  • Reference intervals were defined, and variations were analyzed concerning age, sex, body morphology, socio-professional categories, excess weight, exercise, and drug use.
  • Significant variations in LDH activity were observed with age, especially in children, and notably influenced by socio-professional groups, with minimal impact from adult morphology.

    • Impact:

    • Provides essential reference data for clinical laboratories and healthcare professionals.
    • Highlights the importance of considering age and socio-economic factors in LDH level interpretation.
    • Contributes to a better understanding of lactate dehydrogenase (LDH) enzyme kinetics in human populations.