Valproic acid amide in the treatment of affective and schizoaffective disorders

During 26-51 months of valproic acid amide treatment of 15 patients with affective and schizoaffective disorders, the authors observed reduction in the number, length and severity of affective episodes, especially mania. In a few patients, "fragmentation" of long and severe relapses into short and mild mania or depression occurred. The number and length of hospital admissions dropped in all patients.