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Particle size analysis of microcapsules.

N J Morris, B Warburton

    The Journal of Pharmacy and Pharmacology
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Standardizing three-walled water-in-oil-in-water (w/o/w) microcapsules requires particle size analysis. A bimodal log-normal distribution model accurately describes the size data for both unicored and multicored microcapsules.

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    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Standardization of three-walled water-in-oil-in-water (w/o/w) microcapsules is crucial for consistent product performance.
    • Microcapsule preparation can result in varied particle morphologies, including unicored and multicored structures.
    • Accurate particle size distribution assessment is essential for quality control and process optimization.

    Purpose of the Study:

    • To determine the most appropriate model for describing the particle size distribution of three-walled w/o/w microcapsules.
    • To establish a method for quantifying the relative percentages of unicored and multicored microcapsules.
    • To aid in the standardization of w/o/w microcapsule preparation.

    Main Methods:

    • Particle size distribution data was collected for three-walled w/o/w microcapsules.

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  • Curve-fitting using least squares minimization was employed to analyze the size data.
  • Unimodal and bimodal log-normal distribution models were tested for applicability.

    • Main Results:

    • The log-normal law, commonly applied to particulate systems, was not suitable for this dataset.
    • A bimodal log-normal distribution model provided the best fit for the microcapsule size data.
    • The bimodal model allowed for the estimation of modal size, standard deviation, and relative percentages of unicored and multicored populations.

    Conclusions:

    • The particle size distribution of three-walled w/o/w microcapsules is best described by a bimodal log-normal distribution.
    • This approach enables the differentiation and quantification of unicored and multicored microcapsules.
    • The findings support the standardization of w/o/w microcapsule preparation through robust particle size analysis.