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Relationship between sine random vibrations, resonance and drug content uniformity
The Journal of Pharmacy and Pharmacology
|April 1, 1984
Summary
Random vibrations generally reduce segregation in ordered powder mixes. While low frequencies and wider bandwidths can cause slight demixing, most mixes remain segregation-free after vibration.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Powder mixing is crucial for pharmaceutical formulations.
- Vibration can induce segregation in ordered powder mixes.
- Understanding vibration effects is key to preventing segregation.
Purpose of the Study:
- To investigate the impact of random vibrations on segregation in ordered powder mixes.
- To compare random vibration effects with single-frequency vibration.
- To identify conditions that may lead to demixing.
Main Methods:
- Prepared ordered powder mixes using Emdex, Dipac, or lactose carriers with potassium chloride.
- Subjected mixes to random vibrations at various frequencies and bandwidths.
- Analyzed drug content variation in samples to assess segregation.
Main Results:
- Random vibration generally resulted in lower coefficients of variation (less segregation) compared to single-frequency vibration.
- Low center-frequencies and wider vibration bandwidths (30 Hz vs. 10 Hz) showed a higher tendency for slight demixing.
- Most ordered mixes were found to be segregation-free after random vibration exposure.
Conclusions:
- Random vibration is generally effective in maintaining homogeneity in ordered powder mixes.
- Careful selection of vibration parameters (frequency, bandwidth) is important to avoid demixing.
- The study provides insights into controlling powder segregation during handling and processing.