[Qualitative and quantitative changes in liver glycoproteins in tetrachloromethane poisoning]

Qualitative and quantitative changes in hepatic tissue glycoproteins and glucosamine glycans are studied after tetrachlormethane intoxication. The experiment is conducted on 40 control and 40 laboratory male white rats, poisoned twice weekly per os with 0.1 ml CP CCI4 per 100 g of body weight, in the form of 50 per cent oil solution. Followed in dynamics (at 14, 30, 45 and 90 days), the newly formed connective tissue appears to be characterized by a reduction of glicoproteins and increase in glucosamine glycans. Qualitative changes are established in the character of polycarbohydrate components - upset stability of their complex with proteins - and in the normal correlation of the various glucosin glycans.