The pharmacokinetic profile of carbidopa in dogs

A pharmacokinetic study of carbidopa in beagle dogs has been carried out after intravenous (4 mg kg-1) and oral (75 mg) administration. An open model of three compartments was the best approach for the pharmacokinetic profile of carbidopa administered intravenously. The estimated biological t1/2 was 5 h and the plasma clearance 0.0053 (litre kg-1) min-1. The oral absorption of carbidopa was almost complete and the absolute bioavailability (F) was 88%.