Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell subsets in the thyroids of mice developing autoimmune thyroiditis.

P Creemers, A A Giraldo, N R Rose

    Cellular Immunology
    |September 1, 1984
    PubMed
    Summary

    Thyroid lesions involve specific T-cell subsets. T-cell populations in the thyroid change over time, with a shift from Lyt-1+ to Lyt-2+ cells, suggesting their role in lesion development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of Six Models to Estimate Ascospore Maturation in Venturia pyrina.

    Plant disease·2019
    Same author

    First Report of Pilidium concavum Causing Tan-Brown Rot on Strawberry Fruit in Belgium.

    Plant disease·2019
    Same author

    Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion.

    Nature communications·2017
    Same author

    Pathologic changes in the cardiac interstitium of mice infected with encephalomyocarditis virus.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Heritability analysis of IgG4 antibodies in autoimmune thyroid disease.

    Autoimmunity·2014
    Same author

    Hashimoto thyroiditis: clinical and diagnostic criteria.

    Autoimmunity reviews·2014

    Area of Science:

    • Immunology
    • Endocrinology
    • Cell Biology

    Background:

    • Thyroid lesions are associated with immune cell infiltration.
    • Understanding T-cell subset roles is crucial for thyroid disease pathogenesis.

    Purpose of the Study:

    • To investigate the distribution and dynamics of T-cell subsets within the thyroid during lesion development.
    • To analyze the changes in T-cell populations in response to mouse thyroglobulin immunization.

    Main Methods:

    • Female CBA/J mice were immunized with mouse thyroglobulin (MTg) and complete Freund's adjuvant.
    • Thyroid cells and peripheral blood leukocytes (PBL) were collected 12-21 days post-immunization.
    • Membrane immunofluorescence was used to analyze lymphocyte subsets (Thy-1+, Lyt-1+, Lyt-2+, sIg+).

    Related Experiment Videos

    Main Results:

    • Thyroid B cells were consistently low (<5%), unlike PBL (19-24%).
    • Thyroid T cells (Thy-1+) decreased over time, replaced by non-T/non-B cells.
    • The Lyt-1+:Lyt-2+ ratio in the thyroid shifted from approximately 7 to 2, indicating a relative increase in Lyt-2+ cells.

    Conclusions:

    • Thyroid lesions are characterized by the accumulation of Lyt-1+ and Lyt-2+ T cells.
    • These T cells, potentially including MTg-reactive, helper, and cytotoxic types, may initiate thyroid lesions.
    • T-cell subset dynamics are critical in the development of autoimmune thyroid disease.