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Age-related irreversible decrease in glutamine synthetase following liver cell proliferation.

C Wu

    Biochemistry International
    |May 1, 1984
    PubMed
    Summary
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    Partial hepatectomy permanently reduced glutamine synthetase in young adult rats, but not in weanling or aged rats. Other methods also decreased this liver enzyme in young adults.

    Area of Science:

    • Hepatology
    • Enzymology
    • Cell Biology

    Background:

    • Partial hepatectomy in young adult rats leads to a sustained decrease in glutamine synthetase activity.
    • Understanding the factors influencing this enzymatic response is crucial for liver regeneration research.

    Purpose of the Study:

    • To investigate the effect of partial hepatectomy and other liver cell proliferation inducers on glutamine synthetase activity across different age groups.
    • To determine if specific procedures can lead to a liver cell line with minimal glutamine synthetase activity.

    Main Methods:

    • Partial hepatectomy was performed on weanling, young adult, and aged rats.
    • Liver cell proliferation was also induced using dietary regimentation and CCl4 poisoning in young adult rats.
    • Glutamine synthetase activity was measured in liver tissue.

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    Main Results:

    • Partial hepatectomy did not cause a lasting decrease in glutamine synthetase activity in weanling and aged rats.
    • Dietary changes and CCl4 poisoning, alongside surgery, resulted in a persistent decrease in enzyme activity in young adult rats.
    • Repeated surgical procedures led to a progressive decline in parenchymal cell glutamine synthetase activity.

    Conclusions:

    • Age significantly influences the long-term impact of partial hepatectomy on liver glutamine synthetase activity.
    • Combined procedures involving liver cell proliferation induction can potentially create liver cell lines with significantly reduced glutamine synthetase.
    • These findings offer insights into modulating specific enzyme activity in liver cells for research purposes.