Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Class III action of beta-blocking agents.

P Taggart, R Donaldson, J Abed

    Cardiovascular Research
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Psychological stress, the central nervous system and arrhythmias.

    QJM : monthly journal of the Association of Physicians·2023
    Same author

    Autonomous atmospheric water seeping MOF matrix.

    Science advances·2020
    Same author

    Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders.

    International journal of cardiology·2018
    Same author

    Mild cognitive impairment: what does the general public know about this health condition?

    Public health·2017
    Same author

    The Treatment of Chronic Dysentery.

    The Indian medical gazette·2017
    Same author

    Mechano-electrical feedback in the clinical setting: Current perspectives.

    Progress in biophysics and molecular biology·2017
    Same journal

    Metabolic crisis and TRPM4 activation cause QT prolongation in TANGO2 deficiency disorder.

    Cardiovascular research·2026
    Same journal

    Personalizing Atrial Fibrillation Therapy: Moving from Genetic Association to Mechanistic Translation.

    Cardiovascular research·2026
    Same journal

    Placental Growth Factor Promotes Endothelial Activation and Inflammatory Remodelling in Pulmonary Hypertension.

    Cardiovascular research·2026
    Same journal

    Endothelial-to-mesenchymal transition (EndMT) in atherosclerosis: mechanisms, models and therapies.

    Cardiovascular research·2026
    Same journal

    The gut-heart axis in cardio-oncology.

    Cardiovascular research·2026
    Same journal

    Proteomic signatures as biomarkers of atherosclerosis burden.

    Cardiovascular research·2026
    See all related articles

    Nadolol, oxprenolol, and sotalol significantly increased ventricular refractoriness in dogs, while atenolol, pindolol, propranolol, and timolol showed no significant effect. This study investigates beta-blocker effects on cardiac electrophysiology.

    Area of Science:

    • Cardiovascular Pharmacology
    • Cardiac Electrophysiology

    Background:

    • Beta-adrenergic blocking agents (beta-blockers) are widely used for cardiovascular conditions.
    • Understanding their effects on cardiac refractoriness is crucial for clinical application.

    Purpose of the Study:

    • To investigate the impact of various beta-blockers on ventricular refractoriness.
    • To compare the electrophysiological effects of atenolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, and timolol.

    Main Methods:

    • Intravenous administration of beta-blockers in open-chested beagle dogs under anesthesia.
    • Measurement of left ventricular epicardial monophasic action potentials (MAP) and paced evoked response (PER).
    • Drugs administered after initial beta-blockade with pindolol or propranolol.

    Related Experiment Videos

    Main Results:

    • Nadolol, oxprenolol, and sotalol significantly prolonged ventricular refractoriness (p < 0.001) for both MAP and PER.
    • Atenolol, pindolol, propranolol, and timolol did not significantly alter MAP or PER.
    • Specific quantitative data for MAP and PER changes are provided for each drug.

    Conclusions:

    • Nadolol, oxprenolol, and sotalol exhibit significant effects on ventricular refractoriness.
    • Other studied beta-blockers (atenolol, pindolol, propranolol, timolol) do not demonstrate significant electrophysiological changes in this model.
    • Results highlight differential effects of beta-blockers on cardiac electrophysiology.