Effect of sucralfate on the bioavailability of indenolol

Effect of concurrent administration of sucralfate on the bioavailability of indenolol in rats has been investigated. Albino rats were administered with lg/kg body weight of sucralfate just before the oral administration of indenolol solution (10 mg/kg), blood samples were collected at 0,15,30,45,60,120,240 and 360 minutes after the administration of drugs. Indenolol concentration was determined spectrofluorometrically, 2,4, and 6-hour Area Under the Curve (AUC) was calculated. The peak indenolol blood concentration was observed at 45th minute of drug administration. The level in rats treated with indenolol alone (2.46 +/- 0.07 microgram/ml) and indenolol along with sucralfate (1.21 +/- 0.06 microgram/ml) suggested more than a 50% decrease. There were 36.4%, 27.2% and 20.4% decrease in 2-hour AUC, 4-hour AUC and 6-hour AUC respectively. The data suggest that sucralfate significantly decreased the absorption of indenolol, especially in the early phase after administration and clinically significant interaction may occur due to concurrent administration of indenolol with sucralfate.