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Studies in constitutionally tall adolescents: somatostatin decrease associated with growth hormone increase after TRH

M Garcia Blanco, D Evain Brion

    Clinical Endocrinology
    |October 1, 1984
    PubMed
    Summary
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    Certain adolescents with constitutional tall stature exhibit a paradoxical growth hormone (GH) response to thyrotropin-releasing hormone (TRH), linked to decreased somatostatin. This suggests reduced somatostatin inhibition may contribute to tall stature in some children.

    Area of Science:

    • Pediatric Endocrinology
    • Growth Hormone Regulation
    • Hormonal Responses

    Background:

    • Constitutional tall stature is a common condition in pediatrics.
    • Growth hormone (GH) secretion is tightly regulated by various factors, including somatostatin and thyrotropin-releasing hormone (TRH).
    • Paradoxical hormonal responses can offer insights into underlying regulatory mechanisms.

    Purpose of the Study:

    • To investigate the relationship between somatostatin levels and GH response to TRH in adolescents with constitutional tall stature.
    • To explore the potential role of somatostatin in the etiology of constitutional tall stature.
    • To understand the neuroendocrine regulation of growth in tall children.

    Main Methods:

    • Plasma somatostatin levels were measured in adolescents with constitutional tall stature.

    Related Experiment Videos

  • Growth hormone (GH) response to TRH stimulation was assessed.
  • A control group or saline infusion was used for comparison.
  • Correlation analysis between somatostatin levels and GH response was performed.

    • Main Results:

    • Adolescents showing a paradoxical GH increase after TRH had a significant fall (60%) in plasma somatostatin.
    • Tall subjects without a GH increase after TRH maintained stable plasma somatostatin levels.
    • TRH administration did not alter somatostatin levels in control or non-responsive tall subjects.

    Conclusions:

    • A decrease in somatostatin's inhibitory effect at the pituitary level may mediate the TRH-induced GH release in some tall adolescents.
    • Reduced somatostatin inhibition could be an etiological factor in certain cases of constitutional tall stature.
    • These findings highlight the complex interplay of hormones in growth regulation.