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Genetically determined antigens of squirrel monkey (Saimiri sciureus) IgG
1Department of Microbiology, Delta Regional Primate Research Center, Tulane University, Covington, LA.
Journal of Medical Primatology
|January 1, 1982
Summary
Squirrel monkey IgG shows genetic variation in alloantigens. Colombian and Peruvian monkeys exhibit greater complexity in these immune system markers compared to Bolivian and Guyanan populations.
Area of Science:
- Immunogenetics
- Primate immunology
- Molecular anthropology
Background:
- Immunoglobulin G (IgG) contains polymorphic antigens (alloantigens) that vary between individuals and populations.
- Understanding IgG alloantigens in non-human primates like squirrel monkeys provides insights into immune system evolution and diversity.
Purpose of the Study:
- To investigate the alloantigenic polymorphism of IgG in squirrel monkeys (Saimiri sciureus).
- To identify distinct IgG allotypes across different subspecies and geographic populations.
Main Methods:
- Preparation of alloantisera through cross-immunizations among four squirrel monkey subspecies.
- Analysis of IgG alloantigens using these prepared alloantisera.
Main Results:
- Demonstrated the occurrence of significant IgG antigenic polymorphism in squirrel monkeys.
- Identified three distinct allotypes within the Fd fragment of IgG.
- Observed greater alloantigenic complexity in Colombian and Peruvian populations compared to Bolivian and Guyanan populations.
Conclusions:
- Squirrel monkey IgG exhibits genetically determined antigenic variation.
- Geographic distribution influences IgG alloantigenic complexity, with central populations showing higher diversity.