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Experimental ocular angiogenesis.

J L Federman, G C Brown, N T Felberg

    American Journal of Ophthalmology
    |February 1, 1980
    PubMed
    Summary
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    Vascularized rabbit eye tissues, like retina and iris, induced new blood vessel growth when implanted in the cornea. Avascular tissues and boiled tissues did not stimulate this neovascularization response.

    Area of Science:

    • Ophthalmology
    • Vascular Biology
    • Tissue Engineering

    Background:

    • Corneal neovascularization is a significant challenge in ophthalmology, potentially leading to vision impairment.
    • Understanding the factors that induce or inhibit corneal neovascularization is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the potential of various vascularized ocular tissues to induce corneal neovascularization in a rabbit model.
    • To determine if avascular tissues or heat-denatured vascular tissues can elicit a neovascular response.

    Main Methods:

    • Autologous vascular and avascular ocular tissues (retina, iris, choroid, optic nerve, extraocular muscle, conjunctiva, cornea, sclera) were implanted into corneal pockets in New Zealand white rabbits.
    • Tissues were also boiled to assess the role of vascular integrity.

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  • The presence and anastomosis of limbal vessels with implants were evaluated.

    • Main Results:

    • Vascular autologous implants, including retina and iris, induced significant limbal neovascularization and vessel anastomosis in 15 out of 29 experiments.
    • Avascular implants (peripheral retina, cornea, sclera) and boiled vascular tissues did not induce neovascularization.
    • V2 carcinoma induced neovascularization from retinal and iris intracorneal implants.

    Conclusions:

    • Vascularized ocular tissues possess angiogenic potential that can stimulate corneal neovascularization.
    • The integrity of vascular structures appears essential for inducing this angiogenic response.
    • This study provides insights into the angiogenic properties of ocular tissues, relevant for corneal transplantation and disease research.