Palmoplantar keratoderma of punctate type: acrokeratoelastoidosis Costa

Area of Science:

• Dermatology
• Genetics
• Histopathology

Background:

• Punctate palmoplantar keratoderma is a rare condition affecting the palms and soles.
• A specific variant observed in Finnish families presented unique clinical and histological features.

Purpose of the Study:

• To clinically, histologically, and ultrastructurally characterize a distinct form of punctate palmoplantar keratoderma.
• To investigate the inheritance pattern and potential associations of this condition.

Main Methods:

• Clinical examination of 10 patients from six Finnish families.
• Histological and ultrastructural analysis of skin lesions.
• Pedigree analysis to determine inheritance patterns.

Main Results:

• Patients exhibited symptomless, transparent, hyperkeratotic papules on palms, fingers, wrists, and soles.
• Histology showed undulating hyperkeratosis; ultrastructural analysis revealed deep dermal elastic fiber alterations.
• Autosomal dominant inheritance was suggested, with some patients presenting knuckle pads and recalcitrant warts.

Conclusions:

• The described condition is considered a variant of acrokeratoelastoidosis Costa.
• This variant of hereditary palmoplantar keratoderma has distinct clinical and ultrastructural findings.