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Related Experiment Videos

Determination and bioavailability of ampicillin.

K Ahmad, A Islam, A Sattar

    Bangladesh Medical Research Council Bulletin
    |June 1, 1977
    PubMed
    Summary

    Spectrophotometry accurately measured ampicillin, comparable to microbiological assays. Bioavailability studies revealed initial serum concentration variations among ampicillin brands, with levels becoming similar after six hours.

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    Area of Science:

    • Pharmacology
    • Analytical Chemistry
    • Microbiology

    Background:

    • Ampicillin is a widely used antibiotic.
    • Accurate quantification and bioavailability assessment are crucial for therapeutic efficacy.
    • Variability in drug products can impact patient outcomes.

    Purpose of the Study:

    • To compare spectrophotometric determination with microbiological assay for ampicillin.
    • To evaluate the bioavailability of different ampicillin brands.
    • To analyze serum ampicillin concentrations over time.

    Main Methods:

    • Spectrophotometric analysis of ampicillin.
    • Microbiological assay for ampicillin quantification.
    • Bioavailability study involving human subjects and multiple ampicillin brands.
    • Serum concentration measurements at specified time points (3 and 6 hours).

    Main Results:

    • Spectrophotometric ampicillin determination yielded results comparable to microbiological assays.
    • Significant variations in serum ampicillin concentrations were observed at 3 hours post-administration among different brands.
    • Serum concentrations of ampicillin brands showed greater similarity at the 6-hour time point.

    Conclusions:

    • Spectrophotometry is a reliable method for ampicillin quantification.
    • Bioavailability differences exist among ampicillin formulations, potentially affecting early therapeutic response.
    • Further investigation into ampicillin brand variability and its clinical implications is warranted.

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