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Basophil mediators and their release, with emphasis on BK-A
The Journal of Investigative Dermatology
|May 1, 1980
Summary
Basophils release large molecules during IgE-mediated events, activating inflammatory pathways. These mediators may play a role in both immediate hypersensitivity and broader inflammatory responses.
Area of Science:
- Immunology
- Inflammation Biology
Background:
- Basophils release small mediators like histamine during IgE-mediated events.
- These small mediators are implicated in inflammatory processes.
Purpose of the Study:
- To describe IgE-mediated secretion of large molecular weight mediators from basophils.
- To investigate the role of these mediators in Hageman factor dependent pathways and inflammatory processes.
Main Methods:
- Analysis of IgE-mediated basophil secretion.
- Investigation of mediator activation of Hageman factor pathways.
Main Results:
- Basophils secrete large molecular weight mediators upon IgE-mediated stimulation.
- These mediators activate Hageman factor dependent pathways, generating bioactive peptides.
Conclusions:
- Large molecular weight basophil mediators influence acute and chronic cell-mediated inflammation.
- These proteases may mediate immediate hypersensitivity and other inflammatory responses.