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[Amino liberation in Brown-Norway rats]
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1980
Abstract:
When injected intravenously with dextran or O-hydroxyethyl derivatives of rutoside, rat Brown Norway BN/Mai Pfd f exhibit a fall in the blood pressure and an increase of vascular permeability with oedema formation. As the rat is genetically deprived of plasmatic prekallikrein an of kininogens, activation of the kinin system is not necessary neither for mast-cell degranulation nor for amine release.