Enumeration of immune interferon-producing cells induced by allogeneic stimulation

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Published on: March 14, 2011

Y Ito, H Aoki, Y Kimura

    Infection and Immunity
    |May 1, 1980
    PubMed

    We succeeded in enumerating interferon-producing cells induced by allogeneic stimulation, and proved that they were indeed T lymphocytes. The peak level of these cells in spleen was attained on day 5 after immunication, was maintained for about 2 days, and declined thereafter. Titers of interferon produced in vitro by sensitized spleen cells were maximum on day 7. This suggests that the maturation of immune interferon-producing cells follows cell proliferation after antigen stimulation.

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