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Murine Model of Allergen Induced Asthma
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Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Is there a specific stimulus of infectious-allergic bronchial asthma?

A D Ado, V N Fedoseeva

    Allergologia Et Immunopathologia
    |January 1, 1980
    PubMed

    Insights

    Pigmented Neisseria species are common in infectious asthma patients. These bacteria, along with others, can sensitize the airways, with Neisseria strains showing high allergenicity due to shared antigens with lung tissue.

    Area of Science:

    • Microbiology
    • Immunology
    • Pulmonology

    Background:

    • Infectious asthma involves a complex bronchial microflora.
    • Pigmented Neisseria species are frequently found in patients with infectious asthma.
    • Several microbial species, including Neisseria, Staphylococci, and Klebsiella, act as sensitizers in the respiratory tract.

    Purpose of the Study:

    • To investigate the role of microbial inhabitants in infectious asthma.
    • To identify specific bacterial species responsible for allergic sensitization in the broncho-pulmonary tract.
    • To explore novel criteria for assessing bacterial allergenicity based on antigenic properties.

    Main Methods:

    • Analysis of bronchial microflora in patients with infectious asthma.
    • Identification of bacterial species with sensitizing properties.
    • Evaluation of antigenic similarities between microbial strains and human lung tissues.

    Main Results:

    • Pigmented Neisseria species (N. perflava, flava, subflava, sicca) are consistently present in patients with infectious asthma.
    • Active sensitization of the broncho-pulmonary tract is linked to Neisseria, Staphylococci, and Klebsiella species.
    • Neisseria strains exhibiting antigenic determinants similar to human lung tissues demonstrate the highest allergenic activity.

    Conclusions:

    • Antigenic mimicry between microbial components and host lung tissues is a key factor in developing asthma allergies.
    • The findings suggest a new approach to evaluating bacterial allergenicity by examining their antigenic characteristics.
    • Targeting microbial antigens that cross-react with lung tissue may offer therapeutic strategies for infectious asthma.

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