Correlated clinical, histopathological, HBV and AFP studies of primary carcinoma liver

This paper presents the clinical and histopathological features of 221 Primary Carcinoma Liver studied over the last eight years. HBsAg studies were carried out in 93, AFP studies in 87 and both HBsAg and AFP in the same serum samples in 78. HBsAg positivity rate by CIEP was 29% and AFP positivity was 52%. There appears to be greater AFP posivity in HBsAg positive group compared to HBsAg negative group. Correlation of cell type with AFP positivity reveals significant greater positivity in clear type. The need for indepth studies to use morphological appearances of cancer cells as simple marker of altered function is suggested. Anti e was positive in 40% of HBsAg positive cases studied for e system, while e antigen was positive in 32%. A very unusual finding of e antigen and Anti e present at the same time in a patient with primary liver carcinoma is documented.