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[Histamine and gastric acid secretion].

C A Gutiérrez Cabano

    Acta Gastroenterologica Latinoamericana
    |January 1, 1980
    PubMed
    Summary

    Histamine H2-receptor antagonists inhibit gastric acid secretion, indicating histamine

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Physiology

    Background:

    • Histamine is a key mediator of gastric acid secretion.
    • Histamine H2-receptor antagonists significantly inhibit gastric acid production.
    • This suggests a crucial physiological role for histamine in digestion.

    Purpose of the Study:

    • To elucidate the physiological role of histamine in gastric acid secretion.
    • To investigate the interactions between histamine and other gastric stimulants.

    Main Methods:

    • Review of studies on histamine H2-receptor antagonists.
    • Analysis of gastric acid secretion in response to various stimuli.

    Main Results:

    • Histamine H2-receptor antagonists inhibit basal, nocturnal, and stimulated gastric acid secretion.
    • Histamine acts as the final common chemical mediator at the oxyntic cell.
    • Potentiation occurs between histamine and gastrin/acetylcholine, but not between gastrin and acetylcholine alone.

    Conclusions:

    • Histamine plays a vital physiological role in regulating gastric acid secretion.
    • Histamine is essential for potentiating the effects of other gastric stimulants like gastrin and acetylcholine.

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