Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute bleomycin toxicity.

D J Ganick, M E Peters, G R Hafez

    The American Journal of Pediatric Hematology/Oncology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A rare case of rapid, fatal bleomycin-induced pulmonary toxicity occurred in an 11-year-old boy with Hodgkin's disease. This swift adverse drug reaction highlights the potential for severe bleomycin lung injury, even in young patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study.

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2013
    Same author

    Triage system for rural hospital emergency services: Determining how long patients can wait.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Synovial sarcoma, a primary liver tumor--a case report.

    Pathology, research and practice·2006
    Same author

    Donor-derived small cell lung carcinoma in a kidney transplant recipient.

    Cancer·2001
    Same author

    Identification of the prostate cancer micro-foci with chromosome 8p deletion at the tumor interface area by histopathological-FISH parallel examination.

    International journal of oncology·2001
    Same author

    Respiratory symptoms at age 8 years in a cohort of very low birth weight children.

    American journal of epidemiology·2001
    Same journal

    Transient abnormal myelopoiesis in Down's syndrome neonates.

    The American journal of pediatric hematology/oncology·1994
    Same journal

    Secondary acute promyelocytic leukemia in a child treated with epipodophyllotoxins.

    The American journal of pediatric hematology/oncology·1994
    Same journal

    Maternal malignancy involving the products of conception: a report of malignant melanoma and medulloblastoma.

    The American journal of pediatric hematology/oncology·1994
    Same journal

    Sphenoid sinus involvement in neuroblastoma.

    The American journal of pediatric hematology/oncology·1994
    Same journal

    Transient lupus anticoagulant associated with prothrombin deficiency: unusual cause of bleeding in a 5-year-old girl.

    The American journal of pediatric hematology/oncology·1994
    Same journal

    Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.

    The American journal of pediatric hematology/oncology·1994
    See all related articles

    Area of Science:

    • Oncology
    • Pharmacology
    • Pulmonology

    Background:

    • Bleomycin is a chemotherapy agent used for Hodgkin's disease.
    • Pulmonary toxicity is a known but typically slower-onset side effect of bleomycin.
    • Acute, fatal bleomycin-induced lung injury is exceptionally rare.

    Observation:

    • An 11-year-old male with Hodgkin's disease developed acute pulmonary toxicity after bleomycin treatment.
    • The patient succumbed to the toxicity within 60 hours of presentation.
    • The patient's immunocompromised status initially prompted consideration of alternative etiologies.

    Findings:

    • This case represents an unusually rapid and fatal course of bleomycin pulmonary toxicity.
    • The rapid onset of severe lung injury challenges existing understanding of bleomycin's toxicity profile.

    Related Experiment Videos

  • Fatal outcomes from bleomycin lung toxicity are not typically documented within such a short timeframe.

    • Implications:

    • Clinicians should be vigilant for rapid-onset pulmonary toxicity in patients receiving bleomycin, regardless of age.
    • This case underscores the need for careful monitoring and prompt management of potential bleomycin-induced lung injury.
    • Further research may be warranted to understand the mechanisms behind acute fatal bleomycin pulmonary toxicity in specific patient populations.