[Biosynthesis of pyrimidine nucleotides in normal and regenerating bone tissue]

RNA from bone tissue of healthy animals exhibited low specific radioactivity, when labelled orotic acid was used as precursor. These data suggest that the ability of sceletogenic cells to carry of formation of pyrimidine nucleotides was low. Labelled orotic acid and uridine were incorporated rapidly into regenerating bone tissue during the last days of the first week after the beginning of the regeneration process, gradually decreasing in course of maturation of the regenerated tissue.