Small virus-like particles in leukosis-like syndrome induced by certain antigens and immunostimulators

A transmissible syndrome which is characterized by splenomegaly and myeloid metaplasia was induced in BALB/c mice by injections of certain homologous and heterologous antigens and complete Freund's adjuvant or dextransulfate. From the plasma of these animals small viruslike particles (30--50 nm) were isolated.