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Related Experiment Videos

Effect of blood viscosity decrease on exercise ST segment depressions in hyperlipidemia.

A G Olsson, M Blombäck, L G Ekelund

    Artery
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    This study investigated blood viscosity and exercise ST segment depression in hyperlipidemia. Lowering blood viscosity did not affect ST segment depression, suggesting coronary atherosclerosis, not viscosity, causes these changes.

    Area of Science:

    • Cardiology
    • Clinical Physiology

    Background:

    • Hyperlipidemia is associated with increased cardiovascular risk.
    • Exercise-induced ST segment depression is a marker of myocardial ischemia.
    • The relationship between blood viscosity and ischemic events in hyperlipidemia requires clarification.

    Purpose of the Study:

    • To investigate the potential link between blood viscosity and exercise-induced ST segment depression in hyperlipidemia.
    • To determine if reducing blood viscosity influences ST segment depression during exercise in hyperlipidemic individuals.

    Main Methods:

    • Blood viscosity was acutely reduced using dextran infusion in two subjects.
    • Nine hyperlipidemic subjects with ST segment depression received clofibrate treatment to lower plasma fibrinogen and serum lipids.

    Related Experiment Videos

  • ST segment depression area was quantified using computer estimation with Frank and CH leads.

    • Main Results:

    • Acute reduction in blood viscosity with dextran infusion appeared to increase ST segment depression during exercise.
    • Clofibrate treatment, aimed at reducing plasma fibrinogen and lipids, did not alter the area of ST segment depression.
    • Despite the importance of fibrinogen in blood viscosity, its reduction did not impact ST segment depression.

    Conclusions:

    • The ischemic ST segment depression observed in hyperlipidemia is unlikely to be caused by increased blood viscosity.
    • Findings suggest that premature subclinical coronary atherosclerosis is a more probable cause of exercise-induced ST segment depression in this population.