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[Generalized varicella and herpes].

F Fakan

    Ceskoslovenska Patologie
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Generalized varicella and herpes simplex virus infections caused death in immunocompromised children and neonates. Autopsies revealed similar organ damage, including necrosis and characteristic intranuclear inclusions.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Virology
    • Immunocompromised Host Research

    Background:

    • Corticosteroid therapy can suppress the immune system, increasing susceptibility to severe infections.
    • Neonates and children with compromised immunity are at higher risk for disseminated viral diseases.

    Observation:

    • Four fatal cases were analyzed: three children with generalized varicella and one neonate with generalized herpes simplex.
    • All patients had received prior corticosteroid treatment, indicating iatrogenic immunosuppression.

    Findings:

    • Post-mortem examinations showed consistent pathological findings in internal organs across all cases.
    • Key findings included disseminated necrosis, mucous ulcers with a leucohistiocytic inflammatory response, and karyorrhectic nuclear disintegration.

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  • The presence of Cowdry A type intranuclear inclusions was a hallmark in all examined tissues.

    • Implications:

    • Disseminated varicella and herpes simplex virus infections represent a significant mortality risk in immunosuppressed pediatric populations.
    • Early recognition of Cowdry A inclusions can aid in diagnosing severe viral infections in vulnerable children.
    • This highlights the critical need for vigilant monitoring and management of infections in pediatric patients undergoing immunosuppressive therapy.