[Noradrenaline as a RNA and Na K ATPase biosynthesis regulator in the neurons]

Noradrenaline (10(-5)M) inhibits the summary RNA synthesis in isolated neurone nuclei. In the presence of the dissolvable cytoplasmic fraction noradrenaline effect is transformed: 3H-UTP inclusion into RNA is activated. Similar results were seen in experiments with adenosine-3',5'-cyclophosphate and previously with acetylcholine. The data obtained indicate the presence of the neurone cytoplasmic factor (factors) interacting with biogenic amines and cyclic nucleotides and influencing RNA synthesis in such a complex. In the cell-free system noradrenaline inhibits Na, K-ATPase synthesis, its effect being directed at RNA synthesis inhibition upon DNA gene of Na, K-ATPase. These findings allow a conclusion that a part of neurone genes undergo noradrenaline control: the expression of several ones is activated and of the other is inhibited--the former being higher than the latter, according to noradrenaline effect on the summary RNA synthesis. Noradrenaline does not influence the glial cell RNA and DNA syntheses.