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Related Experiment Videos

Antigenic relationships among various interferon species.

Y Kawade, Y Yamamoto, J Fujisawa

    Annals of the New York Academy of Sciences
    |January 1, 1980
    PubMed
    Summary

    Mouse interferon comprises two distinct types, F and S. Type I mouse interferons share antigenic similarities with L-cell interferons, and Interferon F shows structural resemblance to human leukocyte interferon.

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    Area of Science:

    • Immunology
    • Virology
    • Biochemistry

    Background:

    • Mouse L-cell interferon exists as two distinct species: F (22-24K) and S (32-40K).
    • Type I mouse interferons, derived from various cell types, also present as two species.

    Purpose of the Study:

    • To characterize the antigenic properties of mouse interferon species.
    • To investigate the relationship between mouse L-cell interferons and other Type I mouse interferons.
    • To explore potential structural similarities between mouse and human interferons.

    Main Methods:

    • Antigenic characterization of mouse interferon species.
    • Neutralization assays using antisera against human leukocyte interferon.

    Main Results:

    • Mouse L-cell interferons (F and S) are antigenically distinct.
    • Various Type I mouse interferons exhibit antigenicities indistinguishable from L-cell interferons.
    • Interferon F is fully neutralized by antiserum against human leukocyte interferon.

    Conclusions:

    • Mouse Type I interferons share common antigenic determinants.
    • Significant structural similarities exist between mouse Interferon F and human leukocyte interferon.

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