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Spinal and cortical evoked potentials in multiple sclerosis.

R Garrick, J G McLeod

    Clinical and Experimental Neurology
    |January 1, 1977
    PubMed
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    Sensory evoked potentials (SEPs) are useful for diagnosing multiple sclerosis (MS). Abnormalities were found in 69% of MS patients, correlating with symptoms and showing deterioration over time.

    Area of Science:

    • Neuroscience
    • Clinical Neurology
    • Electrophysiology

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
    • Accurate diagnosis and monitoring of MS progression are crucial for patient management.
    • Electrophysiological tests like sensory evoked potentials (SEPs) can assess nervous system function.

    Purpose of the Study:

    • To evaluate the diagnostic utility of spinal and cortical sensory evoked potentials (SEPs) in multiple sclerosis (MS).
    • To assess the role of SEPs in the ongoing evaluation and monitoring of MS patients.
    • To correlate electrophysiological findings with clinical symptoms and disease progression.

    Main Methods:

    • Performed spinal and cortical sensory evoked potentials (SEPs) after stimulating the median and lateral popliteal nerves.

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  • Included patients with definite multiple sclerosis.
  • Correlated SEP results with clinical sensory signs and symptoms.
  • Conducted follow-up studies to assess disease progression.

    • Main Results:

    • Abnormal SEPs were detected in 69% of patients with definite MS.
    • Abnormal spinal evoked potentials (SEPs) after median nerve stimulation occurred in 52% of patients.
    • Further abnormalities were found in cortical SEPs or spinal SEPs from lateral popliteal nerve stimulation in additional patients.
    • A strong correlation existed between abnormal clinical sensory findings and electrophysiological abnormalities.
    • Longitudinal studies revealed gradual deterioration in one or more SEPs in 50% of patients over time.

    Conclusions:

    • Sensory evoked potentials (SEPs) are a valuable tool for diagnosing multiple sclerosis (MS).
    • SEPs can aid in the objective assessment of neurological deficits and disease progression in MS.
    • The electrophysiological abnormalities detected by SEPs correlate well with clinical manifestations of MS.