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Circulating immune complexes in Sjögren's syndrome.

Y Ichikawa, M Takaya, S Arimori

The Tokai Journal of Experimental and Clinical Medicine

|October 1, 1980

Summary

Circulating immune complexes (IC) were found in over half of Sjögren

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Area of Science:

Rheumatology
Immunology
Internal Medicine

Background:

Sjögren's syndrome (SjS) is a chronic autoimmune disease primarily affecting exocrine glands.
The role of circulating immune complexes (IC) in SjS pathogenesis and systemic involvement remains an area of investigation.

Purpose of the Study:

To investigate the presence and significance of circulating immune complexes (IC) in patients with Sjögren's syndrome (SjS).
To correlate IC levels with disease activity, systemic manifestations, and specific clinical features in SjS.

Main Methods:

Utilized the 125I-Clq binding assay to detect and quantify circulating immune complexes (IC) in Sjögren's syndrome (SjS) patients.
Correlated IC detection with clinical data, including presence of systemic lupus erythematosus (SLE), other associated diseases, erythrocyte sedimentation rate (ESR), serum gammaglobulin levels, and sialographical findings.

Main Results:

Circulating immune complexes (IC) were detected in 52% of Sjögren's syndrome (SjS) patients.
A high incidence of IC (80%) was observed in SjS patients with co-existing systemic lupus erythematosus (SLE).
IC were present even in 40% of SjS patients without other defined diseases, and their levels correlated positively with ESR, serum gammaglobulin, and severity of parotid gland sialographical changes.

Conclusions:

Circulating immune complexes (IC) are frequently present in Sjögren's syndrome (SjS) patients, irrespective of associated diseases.
The presence and levels of IC are associated with systemic manifestations and disease severity in SjS.
These findings support the role of circulating IC in the advancement and systemic involvement of Sjögren's syndrome.

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