Histopathologic and clinical associations of scleritis and glaucoma

Of 92 enucleated eyes with scleral inflammation and 114 eyes from 81 patients with scleritis, 45 (49%) and 20 (18%), respectively, showed evidence of increased intraocular pressure. Damage to the trabecular meshwork of iridocyclitis, overlying corneoscleral inflammation, or peripheral anterior synechiae was the most common cause of increased intraocular pressure. Other causes included topical corticosteroid use, angle neovascularization, and posterior scleritis with secondary angle closure.