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Prolactin secretion in benign prostatic hypertrophy.

L Giuliani, D Pescatore, C Giberti

    European Urology
    |January 1, 1981
    PubMed
    Summary
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    Patients with benign prostatic hypertrophy show increased prolactin reserve. Prolactin response after surgery was higher than before surgery, suggesting a role for prolactin in benign prostatic hypertrophy development.

    Area of Science:

    • Endocrinology
    • Urology
    • Oncology

    Background:

    • Benign prostatic hypertrophy (BPH) is a common condition in aging men.
    • The role of hormones, including prolactin, in BPH pathogenesis is not fully understood.

    Purpose of the Study:

    • To evaluate prolactin secretion in patients with BPH.
    • To investigate the effect of thyrotropin-releasing hormone (TRH) stimulation on prolactin levels in BPH patients.
    • To assess changes in prolactin response after surgical intervention for BPH.

    Main Methods:

    • Prolactin levels were measured in 22 BPH patients before and after TRH stimulation.
    • The TRH stimulation test was repeated in 11 patients post-surgery.
    • Statistical analysis was used to compare prolactin responses.

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    Main Results:

    • Patients with BPH exhibited an increased prolactin reserve.
    • The prolactin response to TRH stimulation was significantly higher in the post-surgical period compared to the pre-surgical period for 11 patients.
    • These findings indicate a dynamic change in prolactin secretion related to BPH and its treatment.

    Conclusions:

    • Elevated prolactin reserve is associated with benign prostatic hypertrophy.
    • Surgical treatment for BPH may influence prolactin secretion.
    • Further research is warranted to elucidate the specific role of prolactin in the development and progression of BPH.