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Related Experiment Videos

A novel molecule expressing HLA-DR antigenic determinants.

S M Goyert, J J Hubert, R A Curry

    Human Immunology
    |September 1, 1980
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) -DR antigen polymorphism arises from structural variations in the beta subunit. This study details differences in alpha and beta subunits across HLA-DRw2, DRw5, and DRw7, suggesting DRw5 may be a distinct human antigen.

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    Area of Science:

    • Immunogenetics
    • Molecular biology
    • Human leukocyte antigens (HLA) research

    Background:

    • Previous research indicated Human Leukocyte Antigen (HLA) -DR antigen polymorphism stems from structural variations in the beta subunit.
    • The human HLA-DR antigens are the functional equivalent of murine I-E antigens.

    Purpose of the Study:

    • To precisely define HLA-DR antigen polymorphism by examining structural variations in alpha and beta subunits.
    • To compare HLA-DRw2, HLA-DRw5, and HLA-DRw7 antigens using monoclonal antibodies and lymphoblastoid cell lines.

    Main Methods:

    • Isolation of HLA-DR antigens from genotypically HLA-homozygous lymphoblastoid cell lines (DRw2, DRw5, DRw7).
    • Analysis of structural differences in the alpha and beta subunits of the isolated HLA-DR antigens.

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  • Utilizing monoclonal antibodies for antigen characterization.

    • Main Results:

    • The alpha subunits of HLA-DRw2 and HLA-DRw7 antigens are structurally very similar.
    • Significant differences were observed in the beta subunits of HLA-DRw2 and HLA-DRw7 antigens.
    • Both alpha and beta subunits of HLA-DRw5 antigen exhibit marked differences compared to HLA-DRw2 and HLA-DRw7.

    Conclusions:

    • HLA-DR antigen polymorphism is significantly influenced by variations in both alpha and beta subunits, with notable differences in beta subunits.
    • The distinct structural profile of HLA-DRw5 suggests it might represent a different human antigen class, potentially analogous to mouse I-A antigens.
    • Further investigation is warranted to clarify the role of the HLA-DRw5 alpha subunit variability and its potential cross-reactivity with other human leukocyte antigen equivalents.