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Nucleolar ultrastructure in psoriatic skin lesions
The Journal of Investigative Dermatology
|October 1, 1981
Summary
Psoriatic skin lesions show altered keratinocyte maturation. Nucleolar changes in these cells suggest inhibited RNA synthesis, impacting skin cell development.
Area of Science:
- Dermatology
- Cell Biology
- Molecular Biology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Keratinocyte abnormalities are central to psoriatic lesion development.
- Nucleolar ultrastructure alterations may indicate cellular dysfunction.
Purpose of the Study:
- To investigate the nucleolar ultrastructure of keratinocytes in psoriatic skin lesions.
- To correlate nucleolar morphology with keratinocyte maturation and RNA synthesis.
Main Methods:
- Ultrastructural analysis of keratinocytes from psoriatic lesions.
- Comparison of nucleoli in psoriatic keratinocytes versus normal keratinocytes.
Main Results:
- Psoriatic keratinocytes exhibited absent segregation of nucleolar components.
- Keratinocytes lacking keratohyalin in psoriatic lesions did not show degranulated nucleoli.
- These findings indicate altered keratinocyte maturation processes in psoriasis.
Conclusions:
- Nucleolar changes in psoriatic keratinocytes are a morphological sign of altered maturation.
- Inhibition of nucleolar (preribosomal) RNA synthesis is implicated in these observed changes.