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Computer support of DNA sequence analysis.

G Osterburg, R Sommer

    Computer Programs in Biomedicine
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces APL programs for DNA sequence data management and analysis. These tools aid in DNA sequencing, fragment assembly, and RNA structure prediction for biological research.

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    Area of Science:

    • Bioinformatics
    • Molecular Biology
    • Computational Biology

    Background:

    • DNA sequencing generates vast amounts of data requiring specialized management and analysis tools.
    • Experimental work in DNA sequencing laboratories necessitates efficient computational support for various tasks.

    Purpose of the Study:

    • To present a package of APL-programs designed for comprehensive DNA sequence data management and analysis.
    • To provide tools supporting both routine laboratory experimental work and more advanced sequence analysis.

    Main Methods:

    • Development of a suite of APL-programs tailored for DNA sequence data.
    • Implementation of algorithms for fragment assembly, restriction site analysis, and homology searching.
    • Inclusion of functions for physical and genetic map plotting and RNA secondary structure prediction.

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    Main Results:

    • The APL-program package offers functionalities for managing and analyzing DNA sequence data.
    • Programs facilitate tasks such as assembling overlapping DNA fragments, identifying restriction sites, and predicting fragment patterns.
    • Advanced capabilities include homology searches, various counting procedures, and graphical representation of RNA secondary structures.

    Conclusions:

    • The described APL-programs provide a valuable resource for DNA sequencing laboratories.
    • The software package enhances the efficiency of DNA sequence data management and analysis.
    • The tools support a range of applications from experimental support to sophisticated structure prediction.