Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adipose tissue cellularity in relation to prognosis for weight reduction.

M Krotkiewski, L Sjöström, P Björntorp

    International Journal of Obesity
    |January 1, 1977
    PubMed
    Summary

    Obesity type impacts weight management. Hypercellular obesity (hyperplastic/combined) shows faster weight gain and regain than hypertrophic obesity, indicating a poorer long-term prognosis despite potential benefits from repeated treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lumbar surgery prior to total hip arthroplasty is associated with worse patient-reported outcomes.

    The bone & joint journal·2017
    Same author

    Risk of early mortality after cemented compared with cementless total hip arthroplasty: a nationwide matched cohort study.

    The bone & joint journal·2017
    Same author

    Substantial rise in the lifetime risk of primary total knee replacement surgery for osteoarthritis from 2003 to 2013: an international, population-level analysis.

    Osteoarthritis and cartilage·2016
    Same author

    Association between hospital procedure volume and risk of revision after total hip arthroplasty: a population-based study within the Nordic Arthroplasty Register Association database.

    Osteoarthritis and cartilage·2015
    Same author

    Body composition through adult life: Swedish reference data on body composition.

    European journal of clinical nutrition·2014
    Same author

    Residual effect after oral bisphosphonate treatment and healthy adherer effects--the Swedish Adherence Register Analysis (SARA).

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014

    Area of Science:

    • Endocrinology
    • Metabolism
    • Human Physiology

    Background:

    • Adipose tissue cellularity differentiates obesity types: hypertrophic, hyperplastic, and combined.
    • Understanding these differences is crucial for predicting weight management outcomes.

    Purpose of the Study:

    • To analyze spontaneous weight development over six years in women with different obesity types.
    • To compare weight reduction and maintenance following a standardized low-energy diet.
    • To investigate the relationship between adipose tissue cellularity, weight change, and relapse rates.

    Main Methods:

    • Ninety obese adult women were classified into hypertrophic, hyperplastic, or combined obesity groups based on adipose tissue cellularity.
    • Spontaneous weight changes were tracked over six years.

    Related Experiment Videos

  • Weight reduction was assessed during a standardized 1100 kcal/day diet.
  • Weight regain and maintenance duration were monitored post-treatment.

    • Main Results:

    • Hyperplastic and combined obesity groups exhibited significantly higher annual weight gain (2.5-3.1 kg) compared to normal weight controls (0.25 kg) and the hypertrophic group.
    • Weight loss during treatment was greatest in the combined (20 kg), hyperplastic (15 kg), and hypertrophic (11 kg) groups.
    • Weight regain was faster and maintenance periods shorter in hyperplastic and combined groups, correlating positively with adipocyte number (FCN).
    • Hypertrophic obesity showed better weight maintenance (51 weeks) compared to hyperplastic (15 weeks) and combined (12 weeks) groups.

    Conclusions:

    • Hypercellular obesity (hyperplastic/combined) has a poorer long-term weight reduction prognosis than hypertrophic obesity due to faster regain.
    • Adipocyte number (FCN) is a key predictor of weight cycling speed and relapse.
    • Despite poorer prognosis, repeated treatments can mitigate the adverse spontaneous weight development in hypercellular obesity.