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Androgen receptor content of normal and hyperplastic human prostate
The Journal of Clinical Endocrinology and Metabolism
|January 1, 1982
Summary
This study found no significant difference in androgen receptor levels between normal and benign prostatic hyperplasia (BPH) tissues. These findings do not support the hypothesis that increased androgen receptors cause BPH.
Area of Science:
- Urology
- Endocrinology
- Molecular Biology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- The role of androgen receptors in BPH pathogenesis is not fully understood.
Purpose of the Study:
- To investigate whether benign prostatic hyperplasia (BPH) is associated with increased androgen receptor content in human prostate tissue.
Main Methods:
- Quantification of nuclear and cytosolic androgen receptor levels.
- Comparison of receptor levels in normal prostate tissue from young men versus hyperplastic and peripheral tissues from older men.
Main Results:
- No significant differences were observed in either cytosolic or nuclear androgen receptor content.
- Androgen receptor levels were consistent across hyperplastic, peripheral, and normal prostate tissues.
Conclusions:
- The study did not find evidence supporting an increase in androgen receptor content in BPH.
- Increased androgen receptor levels do not appear to be a key factor in the development of human BPH.