Characterization of catecholamine binding sites in the rat brain

A systematic study of the effect of neurotoxic agents upon neurotransmitter binding to specific receptors requires the simultaneous assay of several closely related ligand-receptor interactions. Conditions are presented which allow the determination of dopaminergic, alpha-noradrenergic and beta-noradrenergic receptor sites within the same brain areas without major overlap of selectivity. As a result, regional distribution of catecholaminergic receptor sites and some characteristics of such binding are described.