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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
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Effect of corticosterone on serum concentrations of alpha 2 micro-globulin and on spermatogenesis in
The Journal of Endocrinology
|February 1, 1982
Abstract:
Treatment of adult male rats with oestradiol-17 beta (50 microgram/100 g body wt per day for 7 days) resulted 14 days later in reduced levels of alpha 2 micro-globulin in serum and inhibition of spermatogenesis. Administration of corticosterone (2 mg/day) for 14 days to oestrogen-treated rats raised the concentration of alpha 2 micro-globulin in the serum and prevented spermatogenic degeneration. It is concluded that endogenous alpha 2 micro-globulin induced by corticosterone may play a role in spermatogenesis in oestrogenized rats.
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