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[Ewing's sarcoma: therapeutic experience (author's transl)].

J Ribeiro-Ayeh, A Walther, C Horrig

    Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
    |January 1, 1982
    PubMed
    Summary

    This study suggests that preoperative chemotherapy can lead to tumor regression in Ewing's sarcoma, potentially avoiding the need for radiation therapy and its associated morbidity. This approach improved surgical outcomes and reduced treatment complications in patients.

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    Area of Science:

    • Pediatric Oncology
    • Skeletal System Neoplasms
    • Chemotherapy

    Context:

    • Ewing's sarcoma treatment historically involved surgery, chemotherapy, and radiation therapy.
    • Radiation therapy is associated with significant long-term morbidity in pediatric patients.
    • Rosen's T-6 and T-2 Protocols represent established chemotherapy regimens.

    Purpose:

    • To evaluate the efficacy of preoperative chemotherapy in achieving tumor regression for Ewing's sarcoma.
    • To assess the feasibility of avoiding radiation therapy in Ewing's sarcoma treatment.
    • To analyze the impact of chemotherapy timing on surgical resection and histological outcomes.

    Summary:

    • Four patients with Ewing's sarcoma were treated with preoperative chemotherapy based on the T-6 and T-2 Protocols.

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  • Chemotherapy induced significant tumor regression, enabling surgical resection in three cases.
  • In two cases, delaying surgery until after two chemotherapy cycles resulted in no malignant cells on histology, suggesting radiation could be omitted.

    • Impact:

    • Demonstrates the potential to avoid radiation therapy in Ewing's sarcoma treatment, thereby reducing treatment-related morbidity.
    • Highlights the importance of chemotherapy timing and its role in optimizing surgical outcomes.
    • Suggests a significant advancement in the management of Ewing's sarcoma, prioritizing less toxic treatment strategies.