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Bladder outflow obstruction treated with phenoxybenzamine.

P H Abrams, P J Shah, R Stone

    Progress in Clinical and Biological Research
    |January 1, 1981
    PubMed
    Summary
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    This study found phenoxybenzamine (PBZ) effectively treats bladder outflow obstruction in men. PBZ improved symptoms like slow stream and hesitancy, with manageable side effects.

    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Bladder outflow obstruction is a common condition in men.
    • Urodynamic assessment is crucial for diagnosing outflow obstruction.

    Purpose of the Study:

    • To evaluate the efficacy and safety of phenoxybenzamine (PBZ) in treating urodynamically proven bladder outflow obstruction.
    • To assess the impact of PBZ on symptomatic and urodynamic parameters.

    Main Methods:

    • A double-blind, placebo-controlled study involving 61 male patients with outflow obstruction.
    • Urodynamic testing and symptom assessment were conducted before and after treatment.

    Main Results:

    • Phenoxybenzamine (PBZ) significantly improved symptoms of slow stream and hesitancy.
    • PBZ decreased prostatic plateau height and area on urethral pressure profile.

    Related Experiment Videos

  • Dizziness was the most frequent side effect but generally well-tolerated.

    • Conclusions:

    • Phenoxybenzamine (PBZ) effectively reduces proximal urethral pressure, alleviating symptoms of bladder outflow obstruction.
    • PBZ is a suitable treatment option for men experiencing symptoms related to obstruction.