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Related Experiment Videos

Experimental pancreatitis after surfactant exposure.

J F O'Leary, R L Goodale, D Jackola

    Surgery, Gynecology & Obstetrics
    |May 1, 1982
    PubMed
    Summary

    Polyoxyethylene hydrogenated castor oil, used in pancreatic duct imaging, caused pancreatitis-like changes in dogs. Residual fatty acids and surface activity may contribute to this toxicity, warranting caution.

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    Area of Science:

    • Gastroenterology
    • Radiology
    • Toxicology

    Background:

    • Endoscopic retrograde pancreatography (ERP) utilizes contrast agents for visualizing the pancreatic duct.
    • Polyoxyethylene hydrogenated castor oil is a surface-active agent used as a pancreatic ductogram enhancer.
    • Potential adverse effects of contrast agents in pancreatic procedures require thorough investigation.

    Purpose of the Study:

    • To evaluate the effects of pancreatic intraductal infusions of polyoxyethylene hydrogenated castor oil in a canine model.
    • To determine the potential toxicity and inflammatory response associated with this contrast agent.
    • To identify factors contributing to the observed adverse effects.

    Main Methods:

    • Retrograde infusions of 5% polyoxyethylene hydrogenated castor oil into the main pancreatic duct of dogs.

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  • Comparison with saline solution control group.
  • Investigation of inflammatory changes following infusions, including pH buffering and direct ductal perfusion.
  • Analysis of inflammatory changes associated with specific fatty acids (oleic and ricinoleic).

    • Main Results:

    • Infusions of polyoxyethylene hydrogenated castor oil induced significantly greater pancreatitis-like changes compared to saline controls.
    • These inflammatory changes persisted even after pH buffering and pressure normalization.
    • Similar inflammatory responses were observed with oleic and ricinoleic fatty acids at concentrations matching the agent's acidity.
    • Free fatty acids and surface activity are postulated as potential contributors to toxicity.

    Conclusions:

    • Polyoxyethylene hydrogenated castor oil may induce pancreatitis-like changes in the pancreas.
    • Residual free fatty acids and the agent's surface-active properties are implicated in its toxicity.
    • Further research and caution are advised before widespread clinical use in endoscopic retrograde pancreatography.