Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reassessing the bipolar-unipolar dichotomy.

M A Taylor, R Abrams

    Journal of Affective Disorders
    |September 1, 1980
    PubMed
    Summary

    The classification of affective disorders into unipolar and bipolar types may be premature. Genetic and treatment data suggest significant overlap, questioning the current diagnostic separation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Case study research: The contextual approach to understanding contemporary radiography practice.

    Radiography (London, England : 1995)·2025
    Same author

    Review and statistical analysis of activity values reported for coastal sands worldwide.

    Chemosphere·2024
    Same author

    Factors Affecting Adherence, Intake, and Perceived Palatability of Oral Nutritional Supplements: A Literature Review.

    The journal of nutrition, health & aging·2022
    Same author

    The relation between stimulated salivary flow and the temporal consumption experience of a liquid oral nutritional supplement.

    Appetite·2021
    Same author

    Early look at the future of healthcare during the COVID-19 pandemic.

    The British journal of surgery·2020
    Same author

    An alternative methodology to determine <sup>210</sup>Pb activity soil profiles.

    Journal of environmental radioactivity·2019

    Area of Science:

    • Psychiatry
    • Genetics
    • Pharmacology

    Background:

    • The current classification of affective disorders distinguishes between unipolar and bipolar types.
    • This dichotomy is a cornerstone of psychiatric diagnosis and treatment.

    Purpose of the Study:

    • To critically review the literature regarding the unipolar/bipolar classification of affective disorders.
    • To evaluate the validity of this dichotomous classification based on genetic, treatment, and biological data.

    Main Methods:

    • Literature review of genetic studies, lithium treatment studies, and biological comparative studies.
    • Analysis of findings in relation to a recent genetic study of affective states.

    Main Results:

    • Genetic studies reveal substantial overlap in liability between unipolar and bipolar disorders.
    • Lithium treatment studies indicate similar clinical responsiveness in both patient groups.
    • Biological studies comparing patient groups are often confounded by state-dependent clinical variables.

    Conclusions:

    • The separation of affective disorders based on polarity may be premature.
    • Alternative strategies are needed to explore heterogeneity within affective disorders.
    • Future research should focus on identifying subtypes beyond the unipolar/bipolar distinction.

    Related Experiment Videos