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Cutaneous histamine-releasing activity of dimethylsulphoxide (DMSO) in guinea pigs
Toxicology Letters
|January 1, 1982
Abstract:
Dimethylsulphoxide (DMSO) induced swelling in guinea pig ears was found to be abolished by H1- and H2-receptor blocking agents. On histological examination of the ears some degranulation of mast cells was seen. It was concluded that the swelling was mediated by histamine release.