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[Reactions of primed lymphocytes (PLT) and their genetic determination (author's transl)]
Lymphocytes of one family member, if cultured in a primary culture with HLA haploidentical lymphocytes of another family member are primed by the foreign HLA haplotype. Primed lymphocytes can recognize cells bearing the priming haplotype in a secondary culture. The kinetics of this reaction (primed lymphocyte typing, PLT) and its genetic regulation were investigated in one family with a HLA-DR homozygous, HLA-D heterozygous member, one family with two HLA-D homozygous probands, one family with a recombination within the HLA system and in three normal families.
Lymphocytes of one family member, if cultured in a primary culture with HLA haploidentical lymphocytes of another family member are primed by the foreign HLA haplotype. Primed lymphocytes can recognize cells bearing the priming haplotype in a secondary culture. The kinetics of this reaction (primed lymphocyte typing, PLT) and its genetic regulation were investigated in one family with a HLA-DR homozygous, HLA-D heterozygous member, one family with two HLA-D homozygous probands, one family with a recombination within the HLA system and in three normal families.