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Sorbitol dehydrogenase (EC.1.1.1.14) polymorphism in human seminal plasma
Annales De Genetique
|January 1, 1982
Summary
Human seminal plasma contains sorbitol dehydrogenase (SORD) enzyme variants. Electrophoresis revealed three phenotypes, suggesting genetic diversity or enzyme modification in SORD expression.
Area of Science:
- Biochemistry
- Human Genetics
- Enzymology
Background:
- Sorbitol dehydrogenase (SORD) is an enzyme found in human seminal plasma.
- Understanding SORD phenotypes is important for genetic and reproductive studies.
Purpose of the Study:
- To determine the electrophoretic phenotypes of sorbitol dehydrogenase in human seminal plasma.
- To investigate the genetic basis of observed SORD phenotypes.
Main Methods:
- Electrophoretic analysis using cellulose acetate as a support medium.
- Analysis of 173 human seminal plasma samples.
Main Results:
- Identification of three distinct SORD phenotypes: slow band, fast band, and combined slow/fast bands.
- Observed phenotypes suggest the presence of at least two alleles at the SORD locus.
Conclusions:
- The observed SORD phenotypes in human seminal plasma can be attributed to genetic polymorphism (two alleles) or post-translational modifications (secondary isozymes).
- Further research is needed to elucidate the exact mechanism of SORD variation.